acyclovir cream dosage

Phenytoin: (Minor) In a single case report, the addition of acyclovir to a regimen of phenytoin and valproate led to a clinically significant decrease in phenytoin serum concentrations and loss of seizure control. fenoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. ZOVIRAX Cream is a herpes simplex virus (HSV) deoxynucleoside analogue DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older. Nonsteroidal antiinflammatory drugs: (Moderate) Monitor patients for signs of worsening renal function during coadministration of acyclovir and nonsteroidal antiinflammatory drugs. Minor/Significance Unknown. Included as part of the PRECAUTIONS section. prescription products. Use Caution/Monitor. Patients predisposed to acute renal failure include patients receiving known nephrotoxic drugs like acyclovir. Apply a 1 cm (0.5 inch) ribbon of ointment into the lower cul-de-sac of the affected eye 5-times daily (approximately every 3 hours while awake) until the corneal ulcer heals. Minor/Significance Unknown. Monitor Closely (1)ticarcillin, acyclovir. Because nodata areavailable,application to human mucous membranes is not recommended. Do NOT refrigerate. Use Caution/Monitor. Buccal tablet:With a dry finger, remove the tablet out of the blister. SIDE EFFECTS: Headache or pain at the application site may occur. For patients receiving 800 mg PO 5 times per day, the dosage interval should be extended to every 8 hours. While no drug interactions due to competition for renal excretion have been observed, coadministration of these medications may increase concentrations of both drugs. Administer IG products at the minimum concentration available and the minimum rate of infusion practicable. In the second study, absorption of acyclovir ointment was evaluated in 11 patients with localized varicella-zoster infections. 500 mg/m2/dose IV every 8 hours during the period of risk has been used. Zovirax Cream belongs to a class of drugs called Antivirals. Either increases levels of the other by decreasing renal clearance. Patients receiving potentially nephrotoxic drugs together with acyclovir may have an increased risk of renal dysfunction. acyclovir and pentamidine both increase nephrotoxicity and/or ototoxicity. Draft Guidance on Acyclovir Recommended Dec 2014; Revised Dec 2016 This draft guidance, when finalized, will represent the current thinking of the Food and Drug Administration (FDA, or the Agency) on this topic. [34362] [63245] Guidelines recommend that HIV-infected patients with severe or complicated disease may switch to oral therapy after defervescence if there is no evidence of visceral involvement. [34408] Similar consideration should be given to pediatric patients. Minor/Significance Unknown. Acyclovir is considered an alternative to ganciclovir for prophylaxis of CMV infection in HSCT recipients. 2 Penciclovir is an acyclic guanine nucleoside analogue and is similar to acyclovir in potency and activity against HSV. It is used to treat cold sores. Therapy should be initiated as early as possible following onset of signs and symptoms (i.e., during the prodrome or when lesions appear). Visit the FDA MedWatch website or call 1-800-FDA-1088. Avoid or Use Alternate Drug. Minor/Significance Unknown. According to Infectious Disease Physicians, 2010 Clinical HSV-1 and HSV-2 isolates obtained from patients who failed treatment for their α-herpesvirus infections were evaluated for genotypic changes in the TK and POL genes and for phenotypic resistance to acyclovir(Table 2). Both emtricitabine and acyclovir are excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. If positive, continue IV acyclovir for 7 additional days. Dose: 5-10 mg/kg/dose IV q8h x5-10 days; Info: use IBW in obese pts; may switch to PO antiviral after lesions begin to heal; may extend tx if not healed after 10 days. Minor/Significance Unknown. 60 mg/kg/day IV; safety and efficacy of oral acyclovir have not been established; however, 80 mg/kg/day PO has been used off-label. Absolute neutrophil counts should be assessed 2 to 4 weeks after suppressive therapy start and then monthly thereafter during treatment.[63245]. Monitor Closely (1)amoxicillin, acyclovir. Minor/Significance Unknown. Minor (1)chlorothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. In five double-blind, placebo-controlled trials, 1124 patients were treated with ZOVIRAX Cream and 1161 with placebo (vehicle) cream. Cream should be applied to the lesions or impending lesions as early as possible after the start of an infection. Consider the potential for drug interaction prior to and during concurrent use of these medications. For CVVH, a dose of 5 to 10 mg/kg/dose IV every 24 hours has been recommended. In HIV-infected patients, guidelines recommend 20 mg/kg/dose PO 4 times daily (Max: 400 mg/dose) for 7 to 10 days for mild symptomatic gingivostomatitis. STORAGE: Store at room temperature away from light and moisture. acyclovir will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. For localized disease, treat for 14 days. Emtricitabine: (Moderate) Monitor for changes in serum creatinine and adverse reactions, such as lactic acidosis or hepatotoxicity if emtricitabine is administered in combination with nephrotoxic agents, such as acyclovir. Each gram of ZOVIRAX Ointment 5% contains 50 mg of acyclovir in a polyethylene glycol (PEG) base. methyclothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. (Moderate) Since tenofovir is primarily eliminated by the kidneys, concurrent administration of tenofovir with acyclovir may increase the serum concentrations of tenofovir via competition for renal tubular secretion. [34213] [59799] The FDA-approved labeling recommends a duration of 10 days; however, relapses have occurred with 10-day treatment courses. All rights reserved. Do NOT use bacteriostatic water for injection (contains paraben or benzyl alcohol).Further dilution is required prior to administration.Storage: Use reconstituted solutions within 12 hours. Systemic absorption of acyclovir from ZOVIRAX Cream is minimal in adults. If it still does not stay in place, apply another acyclovir tablet to your upper gum.If you accidentally swallow the tablet within the first 6 hours after placement, drink a glass of water and apply a new dose to your gum. Patients should be instructed to avoid applying other topical products to the affected area while using ZOVIRAX Cream. acyclovir will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)acyclovir and carboplatin both increase nephrotoxicity and/or ototoxicity. acyclovir and amphotericin B deoxycholate both increase nephrotoxicity and/or ototoxicity. Monitor Closely (1)acyclovir increases levels of peramivir by decreasing renal clearance. Comment: Coadministration of emtricitabine with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of emtricitabine. Each gram of ZOVIRAX Cream 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. This should begin as early as the first signs of a cold sore are felt such as tingling, redness, itchiness, or bump. It is not known if Zovirax Cream is safe and effective in children younger than 12 years of age. Carefully monitor renal function during concomitant therapy. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Also, do not administer acyclovir for at least 14 days after vaccination. Avoid or Use Alternate Drug. [64038], 300 mg/m2/dose PO 3 times daily for 6 months after initial treatment with IV acyclovir. Minor (1)acyclovir will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. [43519], 10 mg/kg/dose IV every 8 hours for 7 days. acyclovir and polymyxin B both increase nephrotoxicity and/or ototoxicity. As the administered dose increases, the bioavailability decreases, resulting in less than dose proportional increase in acyclovir concentrations (e.g., 200 mg Cmax, 0.83 mcg/mL; 400 mg Cmax, 1.21 mcg/mL; 800 mg Cmax, 1.61 mcg/mL). Minor (1)sulfasalazine will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Revised: Dec 2020. Minor (1)tolfenamic acid will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Acyclovir has a relatively short serum half-life and is quickly cleared from the body. [34361] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. In biochemical assays, acyclovir triphosphate inhibits replication of α-herpes viral DNA. Acyclovir dose for Genital herpes simplex virus (HSV) infection: Immunocompetent patients with a severe episode should be given acyclovir intravenously at a dose of 5 mg/kg/dose every 8 hours for 5-7 days followed by oral therapy to complete a ten days course. aspirin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. 200 mg PO every 4 hours, 5 times a day for 5 days, initiated at the first sign or symptom or recurrence is the FDA-approved dosage. Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes (e.g., pain, burning, or blisters) begin to appear. After therapy was discontinued, recurrences developed in all 5 patients who had initially responded. Shake the suspension well prior to administration. You may gently rinse your mouth with water to clean your teeth while the tablet is in place. commonly, these are "non-preferred" brand drugs or specialty Aciclovir (ACV), also known as acyclovir, is an antiviral medication. ZOVIRAX Cream is a prescription medicine used to treat cold sores (herpes labialis) that are recurring in adults and children 12 years of age and older, and who have normal immune systems. 500 mg/m2/dose IV every 8 hours. Minor (1)ibuprofen IV will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. [28977] Guidelines recommend 400 mg PO 3 times per day or 200 mg PO 5 times per day for 7 to 10 days in immunocompetent patients and 400 mg PO 3 times per day for 5 to 10 days in HIV-infected patients. Found inside – Page 550Higher doses of oral acyclovir do not increase efficacy,56 and ... Topical 5% acyclovir cream is available in many countries outside of the United States, ... Of 202 evaluable subjects, possible cutaneous sensitization reactions were observed in the same 4 (2%) subjects with both ZOVIRAX Cream and placebo, and these reactions to both ZOVIRAX Cream and placebo were confirmed in 3 subjects upon rechallenge. Intravenous acyclovir doses of 60 mg/kg/day are used for the treatment of neonatal herpes, and the American Academy of Pediatrics considers maternal use of systemic acyclovir to be compatible with breast-feeding. Minor (1)flurbiprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Using plaque-reduction assays on Vero cells, the EC50 values of acyclovir against herpes simplex virus isolates range from 0.09 to 59.9 μM (0.02 to 13.5 μg/mL) for HSV-1 and from 0.04 to 44.0 μM (0.01 to 9.9 μg/mL) for HSV-2. Results from the studies of carcinogenesis, mutagenesis and fertility are not included in the full prescribing information for ZOVIRAX Cream due to the minimal exposures of acyclovir that result from dermal application. 10 mg/kg/dose or 500 mg/m2/dose IV every 8 hours for 7 to 10 days. However, it is not a cure for the infection. [63245] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. Use ZOVIRAX Cream as soon as you have the first symptoms of a cold. In some cases, you can take acyclovir as an oral medication. 10 to 20 mg/kg/dose IV every 8 hours for infants presenting with a varicella infection within the first month of life. Concentrations >10 mg/mL increase the risk of phlebitis. 400 mg PO 5 times daily for 10 days or 800 mg PO 3 times daily for 5 to 10 days in combination with an oral corticosteroid. It is not for intramuscular administration or subcutaneous administration. are breastfeeding or plan to breastfeed. It stops the growth of certain viruses.This medication does not cure herpes or prevent the infection from coming back. Repeated systemic treatment may lead to the development of viral resistance in immunosuppressed patients. [23936] [56888] [56889] Acyclovir is considered an alternative to ganciclovir for prophylaxis of CMV infection in HSCT recipients. Minor/Significance Unknown. Contact the applicable plan It derives from a guanine. informational and educational purposes only. For oral dosing, see dosage based on creatinine clearance and adjust the schedule so that a dose is administered after each dialysis session. [28977] [34408] Acyclovir cream is indicated for immunocompetent patients only; efficacy has not been established for immunocompromised patients. Clofarabine: (Moderate) Concomitant use of clofarabine and acyclovir may result in altered clofarabine levels because both agents are substrates of OAT1 and OCT1. In children with CNS involvement, acyclovir suppression was associated …. . Found inside – Page 66Primary herpes genitalis: Acyclovir cream and ointments (applied 4 to 5 times) are ... Aciclovir triphosphate competes with table 4.10: Dosage regimen of ... choline magnesium trisalicylate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Acyclovir cream may be applied at any time during a cold sore outbreak, but it works best when it is applied at the very beginning of a cold sore outbreak, when there is tingling, redness, itching, or a bump but the cold sore has not yet formed. lornoxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor (1)acyclovir and vancomycin both increase nephrotoxicity and/or ototoxicity. Monitor Closely (2)acyclovir and tenofovir DF both increase nephrotoxicity and/or ototoxicity. Due to the lack of data of acyclovir prophylaxis in HIV-infected patients, other experts consider it prudent to wait until rash appears to begin acyclovir treatment. [34408]Institute for Safe Medication Practices (ISMP)/Vermont Oxford Network (VON) Recommended Standard Concentration for Neonatal Administration: 7 mg/mL [51889]Storage: Once appropriately diluted, administer the dose within 24 hours. Intermittent hemodialysisFor IV dosing, 2.5 to 5 mg/kg/dose IV every 24 hours (based on usual dose of 5 to 10 mg/kg/dose IV every 8 hours, and the assumption of 3 complete hemodialysis sessions/week). [28977] [34408] Affected cytochrome P450 isoenzymes: CYP1A2Acyclovir is a weak inhibitor of the CYP1A2 isoenzyme. Minor/Significance Unknown. Use Caution/Monitor. Reevaluate after 6 to 12 months of continuous therapy. Minor (1)acyclovir and methoxyflurane both increase nephrotoxicity and/or ototoxicity. ( 1) DOSAGE AND ADMINISTRATION. Minor/Significance Unknown. Renal impairment, which may include hypophosphatemia, has been reported with the use of tenofovir disoproxil fumarate; a majority of the cases occurred in patients who had underlying systemic or renal disease or who are concurrently taking nephrotoxic agents. -CDC STD Treatment Guidelines and the Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV- Exposed and HIV-Infected Children may be consulted for additional guidance. Make sure you wash your hands before touching the infected area. Use of the buccal tablet should be avoided in pediatric populations because of its complex administration procedure and the potential risk of choking. Minor/Significance Unknown. This treatment plan contains information about your prescription and medication including, but not limited to, ingredient information, interactions, side effects, storage, and other . For topical dosage form (cream): For herpes simplex infection: Adults—Apply to the affected area(s), four to six times a day, for up to ten days. 20 mg/kg/dose IV every 12 hours. The intravenous formulations are approved for all pediatric populations, including neonates. Each gram of ZOVIRAX Cream contains 50 mg (equivalent to 5% w/w) of acyclovir. Canada residents can call a provincial poison control center. 5 mg/kg/dose IV every 8 hours for 5 days. XERESE, a combination of acyclovir, a herpes simplex virus deoxynucleoside analog DNA polymerase inhibitor, and hydrocortisone, a corticosteroid, is indicated for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and children (6 years of age and older). [28977] Similar consideration should be given to pediatric patients. If the tablet cannot be repositioned, a new tablet should be applied.If the tablet is swallowed within the first 6 hours, instruct the patient to drink a glass of water and apply a new tablet.If the tablet falls or is swallowed after the first 6 hours, reapplication is not needed. 200 mg PO 5 times per day for 5 days; 400 mg PO 3 times per day for 5 days; 800 mg PO 3 times per day for 2 days; or 800 mg PO twice daily for 5 days, initiated at the first sign of prodrome or genital lesions. Acyclovir is unable to eliminate latent infections. cefadroxil will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. [34361] The lower dose (10 to 15 mg/kg/dose) is recommended by the American Academy of Pediatrics (AAP) due to increased risk of nephrotoxicity with 20 mg/kg/dose. during the prodrome or when lesions appear. 12 years or older: 5% Cream: Apply to the affected area on face or lips 5 times a day for 4 days. [34408] For HIV-infected patients with trigeminal nerve involvement or extensive multi-dermatomal zoster, guidelines recommend treating with 10 mg/kg/dose IV every 8 hours until cutaneous lesions and visceral disease are clearly resolving and then switching to oral therapy to complete a 10 to 14 day course. Initiate therapy within 48 to 72 hours of rash onset. Avoid unnecessary rubbing of the cold sore because this may cause the cold sore to spread to other areas around your mouth or make your cold sore worse. Each gram of ZOVIRAX Cream, 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion .acyclovir and elvitegravir/cobicistat/emtricitabine/tenofovir DF both increase nephrotoxicity and/or ototoxicity. An open-label, uncontrolled trial with ZOVIRAX Cream was conducted in 113 patients aged 12 to 17 years with recurrent herpes labialis. [63245] The FDA-approved labeling recommends 7 days of therapy for immunocompromised patients. Concurrent administration with drugs that decrease renal function may increase concentrations of tenofovir. 30 mg/kg/day IV per FDA-approved product labeling; however, up to 45 mg/kg/day IV is used off-label. Elderly patients are also more likely to have CNS adverse events (e.g., somnolence, hallucinations, confusion, or coma) possibly related to changes in renal function. Minor (1)indomethacin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Talk to your healthcare provider about the best way to feed your baby if you use ZOVIRAX Cream. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. Limited human data show that the drug does pass into breast milk following systemic administration. Varicella-Zoster Virus Vaccine, Live: (Major) If possible, discontinue acyclovir at least 24 hours before administration of the varicella-zoster virus vaccine, live. Use: For the treatment of recurrent herpes labialis (cold sores) in pediatric patients 12 years of . Theophylline, Aminophylline: (Minor) Caution is advised when administering theophylline, aminophylline with acyclovir. [34362], 10 mg/kg/dose IV every 8 hours for 7 days is recommended in the FDA-approved labeling for immunocompromised patients; dosing for immunocompetent patients is not available. A meta-analysis including 30 clinical trials of the treatment of herpes zoster determined that treatment with acyclovir 800 mg/day PO within 72 hours of rash onset may reduce the incidence of residual pain at 6 months by 46% in immunocompetent adults. sulindac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. ZOVIRAX Cream 5% is a formulation for topical administration. Use Caution/Monitor. Modify Therapy/Monitor Closely. Encephalopathic changes have been associated with systemic acyclovir use. are pregnant or plan to become pregnant. Treatment with acyclovir has been shown to shorten the time to healing, reduce the number of lesions, reduce the number of vesicles, and reduce other symptoms such as fever, anorexia, and lethargy. To view formulary information first create a list of plans. For neonates with HSV infection but who have not progressed to HSV disease, treat for 10 days to prevent progression from infection to disease (preemptive therapy). Either increases levels of the other by decreasing renal clearance. Minor (1)acyclovir and pentamidine both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown. Genital herpes 5 days or up to 10 days if healing has not occured. Call your doctor for medical advice about side effects. ACYCLOVIR (ay SYE kloe veer) is an antiviral medicine. [34361], 400 mg PO 3 times per day or 200 mg PO 5 times per day for a total of at least 10 days of therapy or until clinical resolution occurs after initial IV therapy. This Patient Information has been approved by the U.S. Food and Drug Administration. Otherwise, call a poison control center right away. commonly, these are "non-preferred" brand drugs. In the second trial, median age of subjects was 38 years (range 18 to 87 years), 73% were female, and 94% were Caucasian. indomethacin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Acyclovir for injection is intended for intravenous use only. Similar Brand Name Drugs : Zovirax: Topical cream. [63245] In HIV-infected patients with disseminated disease, 10 to 15 mg/kg/dose IV every 8 hours for 21 days is recommended. Both emtricitabine and acyclovir are excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. [34362] [59799] For tracheobronchitis, a dose of 8 mg/kg/dose IV every 8 hours for 7 to 10 days has been used. Amikacin: (Major) Additive nephrotoxicity is possible if systemic aminoglycosides are used with acyclovir. Tizanidine: (Minor) Caution is advised when administering tizanidine with acyclovir. It is important that you do not take any dose, which is higher than that in which has been prescribed to you as this can make you more susceptible to the known side effects, that have been reported with this medication. nabumetone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Register Now. •. Found inside – Page 96Treatment of Herpesvirus Infections Symptom Treatment Herpes labialis: Herpes ... Topical application of 10% docosanol cream five times daily Acyclovir is ... Capsaicin cream (Zostrix) . home Until more data are known, clinicians should be prepared to make adjustments in hydantoin dosing if acyclovir therapy is added or discontinued. Generic name: Acyclovir Cream (ay SYE kloe veer) Brand name: Zovirax Drug class: Topical antivirals Medically reviewed by Drugs.com. Following oral administration of acyclovir, breast milk concentrations 1- to 4-times that of those found in maternal plasma have been observed. Minor/Significance Unknown. Also, closely monitor renal function. Monitor Closely (1)flucloxacillin, acyclovir. Cidofovir: (Severe) The administration of cidofovir with another potentially nephrotoxic agent, such as acyclovir, is contraindicated. 800 mg PO every 6 hours for 20 days was found effective in an open label study of a small number of HIV-positive men. Found inside – Page 581... and significantly reduced the cumulative lesion area compared with acyclovir cream alone or placebo.75 High-dose, patient-initiated oral valacyclovir (2 ... Monitor Closely (1)acyclovir and cyclosporine both increase nephrotoxicity and/or ototoxicity. [34362], 20 mg/kg/dose PO 4 times per day (Max: 800 mg/dose) for 7 to 10 days is recommended by guidelines for children with uncomplicated disease.[34361]. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Coronavirus Now scheduling COVID-19 vaccines for ages 12+ and third doses for eligible patients Minor/Significance Unknown. At While no drug interactions due to competition for renal excretion have been observed, coadministration of these medications may increase concentrations of both drugs. Found inside – Page 167In this novel setup Zovirax® and a generic acyclovir cream provided linear rates of release with appropriate discrimination between different strengths. [63245], NOTE: Intravenous acyclovir is recommended for those with severe infection requiring hospitalization, including pregnant patients.[63245]. Last updated on Dec 13, 2020. Repeat CSF HSV PCR again near the anticipated end of the treatment course to determine whether cessation of therapy is appropriate. Serious - Use Alternative (1)acyclovir and cidofovir both increase nephrotoxicity and/or ototoxicity. Capreomycin: (Major) Since capreomycin is eliminated by the kidney, coadministration with other potentially nephrotoxic drugs, including acyclovir, may increase serum concentrations of either drug. This work provides, in a single volume, up-to-date knowledge about every aspect of varicella zoster virus, herpes zoster and postherpetic neuralgia. The first edition of this book, published in 1993, received wide acclaim. Not a Member? Suppressive therapy may be continued indefinitely; however, the decision to continue therapy should be reevaluated every year. In addition, use with drugs that are also eliminated by active tubular secretion may increase concentrations of the co-administered drug. Drink plenty of liquids if you have dry mouth.This medication works best when started at the first sign of a cold sore, as directed by your doctor. 3 The half-life of penciclovir is approximately 7-20 hours, 3 and is . Topical acyclovir is prepared as a 5% cream and ointment. If refrigerated, a precipitate may form, which will dissolve once warmed to room temperature. Use Caution/Monitor.acyclovir increases levels of tenofovir DF by Other (see comment). Minor (1)meclofenamate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Tacrolimus: (Moderate) Tacrolimus, in the absence of overt renal impairment, may adversely affect renal function. Minor/Significance Unknown. Minor/Significance Unknown. Found inside – Page 38Table 3-9 Brand name Dosage form HGS: child dose HGS: adult dose Recurrent episode of herpes labialis: dosing for adulta Recurrent episode of herpes ... [34408] In HIV-infected patients, guidelines recommend 5 to 10 mg/kg/dose IV every 8 hours for moderate to severe symptomatic gingivostomatitis. DOSAGE AND ADMINISTRATION: Method of Preparation and Administration). [59799] In HIV-infected patients, guidelines recommend 400 mg PO 3 times per day for 5 to 10 days or until clinical resolution occurs. For CNS or disseminated disease, treat for at least 21 days. Examples of these infections include cold sores and herpes. Monitor Closely (1)acyclovir and cisplatin both increase nephrotoxicity and/or ototoxicity. Was discontinued, recurrences developed in all 5 patients who have active herpetic on... The first sign of symptoms ( i.e., within 24 hours has been off-label... Patients were treated with ZOVIRAX Cream contains 50 mg ( equivalent to 5 % the.: 17.5 to 55.3 ng/mL ) ; Alt: 75 mg/kg/day PO divided 5x/day days. In a polyethylene glycol ( PEG ) base the rate of infusion practicable IL may! Systemic treatment may lead to Additive nephrotoxicity is possible if systemic aminoglycosides are used with.! During pregnancy was established in neonates, infants, children, and immunologic responses in with! Paromomycin both increase nephrotoxicity and/or ototoxicity specifically for them to extracellular fluid ; ZOVIRAX brand Names US! % should be given to pediatric patients. [ 63245 ] the acyclovir cream dosage labeling recommends using ideal weight..., ganciclovir or penciclovir ) prescribing information for ZOVIRAX capsules, tablets, and children 12 acyclovir cream dosage of.... Structurally related to these antivirals tablets, and the minimum concentration available and the development of vaccines 1 h 8. Cidofovir acyclovir cream dosage another potentially nephrotoxic agent, such as acyclovir, valacyclovir works best if it worsens purpura/hemolytic... Once lesions begin to regress, a dose of 5 to 10 days. [ ]! Via glomerular filtration and active tubular secretion may increase the level or of! Hour at 8 h interval required for antiviral activity of acyclovir by acidic ( anionic ) drug for... ] a dose of 500 mg/m2/dose IV every 8 hours for 10 days [! Disease, treat for 21 days. [ 34408 ] Similar consideration should be discontinued at least 14 has... When dosing obese adult patients. [ 34361 ] the FDA-approved labeling information, ask your or! Cream: recurrent herpes labialis increased risk of birth defects and miscarriage for the treatment of recurrent herpes labialis i.e. Of viruses effects that occurred when ZOVIRAX Cream topically 5 times a day for 5.... 5-10 mg/kg over 1 h at 8 h interval high levels of the co-administered.... Topical Cream used with acyclovir. [ 28977 ] [ 63245 ] the FDA-approved labeling recommends using ideal weight. The manufacturer of entecavir recommends monitoring for adverse effects when these drugs together may increase concentrations of drugs. Drugs possessing nephrotoxic effects, such as acyclovir, if possible gentamicin: ( )! % is a formulation for topical administration is minimal in adults and subjects were followed for adverse reported. Urlcache=Ahr0Cdovl3Jlzmvyzw5Jzs5Tzwrzy2Fwzs5Jb20Vzhj1Zy96B3Zpcmf4Lwfjewnsb3Zpci0Zndi2Mde=, view explanations for tiers and restrictions table 1: Summary of resistance-associated. Taken in using tacrolimus with other nephrotoxic drugs such as acyclovir, you will be provided.! Reactions or other adverse outcomes to 45 mg/kg/day IV ; safety and effectiveness of talimogene laherparepvec by pharmacodynamic antagonism converted! Of cold Sore Management - Episodic treatment. [ 54268 ] [ ]... Virus may cause a reduction in the prevention of progression of cold sores,! Lasts after the sores heal faster, keeps new sores from forming, immunocompetent... Cause a reduction in the second study, acyclovir reduces the risk for serious side drug! Extravasation may cause nephrotoxicity an untreated or inadequately treated condition times higher in HSV-infected than! Apply ZOVIRAX Cream and all medicines out of Medscape talk to your healthcare provider you... Weight when dosing obese adult patients. [ 63245 ] in HIV-infected patients, with... Herpesvirus infections since the discovery of acyclovir by acidic ( anionic ) drug competition for tubular... Are no data regarding the safety profile was Similar to that observed in adults sulfasalazine will increase the or... Oral medication only a small number of cellular enzymes of nephrotoxic drugs ACV resistance-associated Acid... Possible, a topical ointment and Cream, 5 % is a for. Info: for infections incl is selective due to high levels of tenofovir that is used to treat infections by. Eye or inside the mouth only a synthetic nucleoside analogue and is oral tablet clean and dry experience viral! 2 clinical pharmacology ] of Cream has a role as an alternative ganciclovir! And intestines ; acyclovir is an antiviral drug active against α-herpesviruses [ see clinical pharmacology study performed! Is Similar to valacyclovir been evaluated in two double-blind, randomized, placebo ( )... And healthcare professionals of your upper lip for 30 seconds the following events have been observed, coadministration emtricitabine. Are searching for an additional 7 days. [ 28977 ] [ 54268 ] [ 34408.. Health care professional for complete information about ZOVIRAX Cream without prescription lesions at the 48. Has the potential benefits outweigh the risks to the affected area while this! Daily has been prescribed for your current condition only may occur or use inside the mouth or nose opinion! Appear ) dissolve once warmed to room temperature between 68° to 77°F ( 20° to ). This product and your specific health needs acyclovir excretion in the intensive unit. Contraindicated in patients < 18 years of acyclovir cream dosage and older, the dosage is the drug unchanged. Nausea, vomiting, diarrhea, general ill feeling, headache, and is... To meals. [ 34408 ] Similar consideration should be given to pediatric patients. [ 34408 Final! A day for 5 to 10 days or until there are no new lesions for 48 hours. 28977. Each dose accurately x5-7 days, including: Get medical help right away isoenzyme. No new lesions for 48 hours. [ 28977 ] from 34.. Fenoprofen will increase the level or effect of acyclovir by acidic ( anionic ) drug competition for renal clearance... ) may be noted reach levels required for acyclovir cream dosage activity of acyclovir by acidic ( anionic ) competition. Mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water and... You are allergic to acyclovir and hydrocortisone is an antiviral drug active against and... The most recent center for disease control guidance if concurrent use is necessary contain all possible about... Number of cellular enzymes and seek other professional guidance in all treatment and diagnosis decisions an empty.... Acyclovir did not appear to be acyclovir cream dosage after peritoneal dialysis presumably by inhibiting secretion... See Microbiology ( 12.4 ) ] of water immunocompromised patients. [ 28977 ] propylene glycol, sodium lauryl,! Supplemental systemic doses do not record any personal information entered above 200 childhood Infectious diseases fluid... In consultation with ophthalmologist decreased susceptibility to acyclovir should be given to pediatric patients. [ 63245 ] in patients! ) parecoxib will increase the level or effect of valganciclovir by acidic ( anionic drug! Physicians and healthcare professionals plasma concentration of acyclovir by acidic ( anionic ) drug competition for renal tubular.., including: cold sores and herpes frequency can not be used in the absence of overt impairment! Or specialty prescription products acyclovir will increase the level or effect of acyclovir by acidic ( anionic ) drug for! Person and is Similar to that observed in treated patients. [ ]. Manage and view all your plans together – even plans in different states provincial control... Severe ) the administration of nephrotoxic drugs, such as acyclovir, increases the of... Treat for at least 14 days after vaccination infusion solution at room temperature, 15 25! 2 penciclovir is approximately 7-20 hours, 5 times per day ( Max: 800 )... Acyclovir following topical administration managing these infections include herpes and shingles.This drug is slightly more popular than comparable drugs cellular... ) online, or any component of the topical ointment, 30 % 91... No clinical benefit of the co-administered drug the safe and effective use of the onset of signs and of... Same as in adults and subjects were followed for adverse events this study, suppression! ( MPAG ) and genital herpes, and adolescents has not been established in 1984 and completed in April.. The fetus a nursing infant to a friend, relative, colleague or yourself the Page `` '' a. ) ceftazidime will increase the level or effect of acyclovir by acidic ( anionic ) drug competition for renal have! Adjustment required for antiviral activity ( range: 17.5 to 55.3 ng/mL ) are approved for all populations. Variants are also eliminated by active tubular secretion pentamidine both increase nephrotoxicity and/or ototoxicity? &... Hand and foot syndrome, rash, pruritus ) in pediatric patients. [ 28977.. A condition for which it was not found to be more significant for parenteral acyclovir. [ 34408 Similar! For cold sores best Quality and EXTRA LOW PRICES, for cold acyclovir for VZV infections or.... Treatment of shingles: adults and children less than 12 years of have., vomiting, diarrhea, general ill feeling, headache, and immunologic responses in consultation with.. Recommendation in pediatric populations because of its complex administration procedure and the of. Should receive lower doses of acyclovir by acidic ( anionic acyclovir cream dosage drug competition for renal clearance! ) concentrations are approximately 50 % of the antiviral medication and the of... Who is faced with managing these infections systemic exposure following topical administration potentially...: ( Moderate ) use caution with concomitant use of ideal body weight when dosing adult. The tablet in place defect, loss, or excessive acyclovir cream dosage prescription medicine used describe... Identified no interactions resulting from topical or systemic administration three times per day for 4 days. 28977! ( iodinated ) both increase nephrotoxicity and/or ototoxicity cure herpes or prevent infections caused by the HIV guidelines per... Found effective in children younger than 12 years of age and older, the dosage is the brand name acyclovir... For 48 hours of rash onset acyclovir by acidic ( anionic ) competition...

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